A Serious Medical Case Confirming the Significance of Clinical Pharmacists’ Role Inside Community Pharmacists

Authors

DOI:

https://doi.org/10.25026/jtpc.v9i2.648

Keywords:

Diclofenac, Ketorolac, Drug-Drug Interactions, Clinical pharmacist, Community Pharmacy

Abstract

Diclofenac and ketorolac are prescribed as nonsteroidal anti-inflammatory drugs (NSAIDs) used to manage pain and inflammation. However, co-administration of them could lead to serious health problems. We seek to highlight the potential dangers of their concurrent use.  We discuss the increased risk of severe gastrointestinal complications, including ulceration, bleeding, and perforation, associated with combining these medications. The case emphasizes the importance of clinician awareness of this drug interaction and advocates for safer prescribing practices. Also, we shed light on the significant role of clinical pharmacists in each community pharmacy, hospital, and medical centre.

Keywords:          Diclofenac, Ketorolac, Drug-Drug Interactions, Clinical pharmacist, Community Pharmacy

Downloads

Download data is not yet available.

References

[1] Vane JR, Botting RM. Mechanism of action of nonsteroidal anti-inflammatory drugs. Inflammation Research. 1999;48(1):827-36.

[2] Dhillon S, Yaffe DG, Jones RN. Drug-drug interactions with psychotropic medications. Centre for Geriatric Medicine. 2010;26(3):635-53.

[3] Hanlon JT, Gagne RP. Prevalence of potentially interacting medication use among elderly ambulatory care patients. Journal of the American Geriatrics Society. 2001;49(2):134-40.

[4] Strom BL, Bohnen JM, Ruiz JM, DeWitt TG, Lip GY. Potential drug-drug interactions associated with antiepileptic drugs. Epilepsia. 2007;48(1):56-65.

[5] Wolfe F, Lichtenstein DR. Gastric ulcers caused by nonsteroidal anti-inflammatory drugs. The American Journal of Medicine. 1977;63(6):879-88.

[6] Raffa RB, Kelly MT, Felts JA, et al. Short-term efficacy and safety of ketorolac tromethamine for postoperative pain. The Journal of Clinical Pharmacology. 1988;28(8):704-10.

[7] Singh G. Gastrointestinal complications of nonsteroidal anti-inflammatory drugs. Journal of Clinical Gastroenterology. 2004;38(6 Suppl 2):S61-66.

[8] Kearney TE, Bailie GR, Bombardier C, et al. Do non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of serious gastrointestinal complications in individuals taking low-dose aspirin? A collaborative meta-analysis. British Journal of Clinical Pharmacology. 2006;61(6):679-91.

[9] Al-Jawabreh A, Mousa HM. Life-threatening interaction between ketorolac and diclofenac. Annals of Pharmacotherapy. 2003;37(11):1676-8.

[10] Boucetta A, El Atrach F, Touhami S, et al. Accidental coadministration of ketorolac and diclofenac: Case report and review of the literature. International Journal of Rheumatic Diseases. 2019;22(11):2038-2041.

[11] Drug Eye. Voltaren. Cited on May 15, 2024. Available from: http://www.drugeye.pharorg.com/drugeyeapp/android-search/drugeye-android-live-go.aspx?gname=3287geno

[12] Moore RA, McQuay HJ, Derry P, et al. Single dose oral diclofenac for acute postoperative pain in adults. Cochrane Database of Systematic Reviews. 2004(2):CD004768.

[13] McCormack PL, Scott LJ. Diclofenac sodium injection (Dyloject®): in postoperative pain. Drugs. 2008;68(1):123–30.

[14] Gan TJ. Diclofenac: an update on its mechanism of action and safety profile. Current Medical Research and Opinion. 2010;26(7):1715–31.

[15] Drug Eye. Ketolac. Cited on May 15, 2024. Available from: http://www.drugeye.pharorg.com/drugeyeapp/android-search/drugeye-android-live-go.aspx?gname=3287geno

[16] Flores Murrieta FJ, Granados Soto V. Pharmacologic properties of ketorolac tromethamine: A potent analgesic drug. CNS Drug Reviews 1996; 2: 75-90

[17] Catapano MS. The analgesic efficacy of ketorolac for acute pain. J Emerg Med. 1996 Jan-Feb;14(1):67-75.

[18] Drugs.com. drug interaction checker. Cited on May 15, 2024. Available from: https://www.drugs.com/drug_interactions.html

[19] Medscape. drug interaction checker. Cited on May 15, 2024. Available from: https://reference.medscape.com/drug-interactionchecker

Downloads

Published

2025-12-31

How to Cite

Amer, A., & Osman, S. (2025). A Serious Medical Case Confirming the Significance of Clinical Pharmacists’ Role Inside Community Pharmacists. Journal of Tropical Pharmacy and Chemistry, 9(2), 71–75. https://doi.org/10.25026/jtpc.v9i2.648

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.